CCD microscopeを用いた体外循環中-逆行性脳灌流時を中心とした-脳微小循環の評価
スポンサーリンク
概要
- 論文の詳細を見る
In aortic arch repair, establishment of safer cerebral protection remains an important issue to reduce cerebral complications. Various cerebral perfusion methods have been utilized for it. The usefulness of retrograde cerebral perfusion (RCP) with hypothermia was recently employed. In the present study, the cerebral microcirculation during RCP was evaluated by direct observation with the use of a charge-coupled device (CCD) microscope. Extracorporeal circulation was established with the arterial perfusion via the femoral artery and venous drainage from the right atrium in 6 craniotomied, and anesthetized swine. The arteriolae and venulae on the brain surface were observed. Each swine was cooled down to a brain temperature of 20℃. Homogeneous vascular flow was observed during antegrade cerebral perfusion (ACP) in all models. Perfusion was discontinued, RCP was initiated with oxygenated blood via the superior vena cava increase of perfusion pressure with stepwisely, and cerebral perfusion pressure (CPP) was gradually increased. Retrograde vascular flow was generated in 4 of the 6 models during RCP, but homogeneous retrograde vascular flow was achieved in the arteriolae and venulae in only 2 swine at a CPP≧20mmHg. These results suggested that homogeneous and effective retrograde perfusion might be achieved in ACP with arterial pressure which might be caused brain edema. However, it might not be achieved in RCP without increase of a CPP<20mmHg, though brain edema might be caused by such a pressure.
- 岐阜大学の論文
- 2003-03-31