ラット肝切除後の門脈血行動態に門脈体循環短絡の及ぼす影響

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We studied the effects of portal-systemic shunt after 70% and 90% hepatectomy on the rats with subcutaneous transposition of the spleen (STS) and temporary total hepatic ischemia (TTHI). Male Wistar rats were divided into 3 groups : Hn group was normal rat, Hs group was with STS, Hsi group was with STS and TTHI Three groups were subjected to 70% or 90% hepatectomy. One hour after hepatectomy, portal blood pressure (PBP) was measured with the polygraph and portal-systemic shunting (PSS) was examined with dye-containing microspheres. In the untreated animals PBP was 5.0 mmHg and the ratio of PSS was 0.2%. After 70% hepatectomy, PBP was 7.2, 8.0, and 7.9 mmHg, in 70 Hn, 70 Hs and 70 Hsi, respectively, and the ratio of PSS was 0%, 0.5% and 1.1%, in 70 Hn, 70 Hs and 70 Hsi, respectively. PBP was increased after 70% hepatectomy compared with the untreated rat, but there were no significant differences in both PBP and the ratio of PSS among the three groups. After 90% hepatectomy, PBP was 13.8, 12.8 and 10.2 mmHg, in 90 Hn, 90 Hs and 90 Hsi, respectively. PBP was significantly lower in 90 His than in 90 Hn and 90 Hs. The ratio of PSS was 1.0, 13.5, 24.8%, in 90 Hn, 90 Hs and 90 Hsi, respectively, and it was significantly higher in 90 Hsi than in 90 Hs and 90 Hn and higher in 90 Hs than in 90 Hn. In conclusion, the animals with TTHI in addition to STS increased the ratio of shunt flow and decreased PBP after 90% hepatectomy.
岐阜大学の論文
2003-03-31