Auto-and Crosscorrelation Analysis to Assess Diurnal Plasma CortisolLevels and Routine Differential Blood Count Parameters

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概要

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• The diurnal courses of cortisol and differential blood count were determined at 08.00 H, 12.00 H, 16.00 H and 20.00 H in 14 healthy male subjects on two subsequent days. Data were analysed descriptively (mean/SD, linear regression) and sine wave models were fitted. Periodicity was investigated by means of autocorrelation. Relations between cortisol levels and hematology parameters were assessed using a crosscorrelation technique. Neutrophils correlated significantly with cortisol levels with a time lag of less than 4 hours. In contrast, the correlation of lymphocytes and cortisol was characterized by a time lag of 4 hours and that of eosinophils at a lag time of 4 hours In conclusion, hematology parameters and plasma cortisol appear to be closely related within a complex feedback network. The character of this interaction between hormonal and hematology parameters may have clinical relevance, and they may replace cortisol measurements if the correlations can be well established.

• 新潟大学の論文

著者

• Koch H

  Psychiatric Univ. Clinic Regensburg Deu

• Raschka C

  Johann‐wolfgang‐goethe Univ. Frankfurt/main

• KOCH HJ

  University of Regensbsburg, Department of Psychiatry, Regensburg

• RASCHKA C

  Wolfgang Goethe University, Frankfurt, Germany

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• Auto-and Crosscorrelation Analysis to Assess Diurnal Plasma CortisolLevels and Routine Differential Blood Count Parameters

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