A Study of Clinical Features and the Worsening Factors Among Patients with Behget's Disease in Japan
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概要
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A cross-sectional survey of Beliefs disease in Japan was held to investigate the correlation of clinical-features and HLA-B51, pathergy test and the worsening factors among patients. The questionnaires were sent to 200 hospitals selected geographically at random in Japan. The diagnosis was made with Japanese Criteria for the classification and patients who did not satisfy the criteria were excluded from the study. The differences in data were analyzed by Pearson's corrected chi-square test, and multiple logistic regression analyses with SPSS. A total of 180 patients (80 men and 100 women) were used as subjects. The rate of positive HLA-B51 was 57.4% (66.7% in men, 44.8% in women). HLA-B51 positivity was significantly higher in patients with eye lesions than without, and significantly lower in patients with gastrointestinal lesions than without. The rate of positive pathergy test was 53.0 % (67.3 % in men, 42.4 % in women). The pathergy test positivity was significantly higher in male patients, patients with skin lesions, and with central nerve system symptoms. The number of patients with worsening factors affecting the symptoms, such as seasonal influences, infectious states, psychological fatigue and physical fatigue was 88, with significantly more among patients with skin lesions and those with arthritis, and less among those with eye lesions. As the results of multiple regression analyses show, HLA-B51 negativity was most associated with patients with gastrointestinal lesions and the positivity was most associated with male patients. The pathergy test positivity was most associated with male patients. It was suggested that the rates of positive HLA - B51 and pathergy test were significantly higher among male patients. As the worsening factors might be concerned with the etiology of Behcet's disease, this study only provided some suggestions for further examination.
- 獨協医科大学の論文
- 2003-10-25
著者
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TAKAHASHI Masanori
Department of Surgery 1, Iwate Medical University
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Nishiyama Midori
Department Of Public Health Sciences Dokkyo University School Of Medicine
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Nishiyama Midori
Department Of Public Health Dokky University School Of Medicine
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NAKAE Kimihiro
Department of Public Health Sciences, Dokkyo University School of Medicine
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Kuriyama Takao
Department of Public Health Sciences, Dokkyo University School of Medicine
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Nakae K
Department Of Health Sciences Minami-kyushu University
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Nakae Kimihiro
Department Of Health Science Minami-kyushu University
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Kuriyama Takao
Department Of Hygiene & Preventive Medicine Faculty Of Health Sciences The University Of Shizuok
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Kuriyama Takao
Department Of Public Health Sciences Dokkyo University School Of Medicine
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Takahashi Masanori
Department Of Legal Medicine Dokkyo University School Of Medicine
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Takahashi Masanori
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Nishiyama Midori
Department of Public Health Sciences, Dokkyo University School of Medicine
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