癌細胞核の力学特性計測(J23-3 マイクロナノ理工学(3),J23 マイクロナノ理工学)

概要

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Cytological diagnoses use optically microscopic observations of fixed cells, extracted from urine, ascites, tissue, etc.. Cancer cells show frequently anomalous appearance of nucleus, such as relatively large nucleus (large N/C ratio). Cytomechanics, recent subject interested in biology, has possible contributions to diagnoses. This study developed a apparatus for measurement of mechanical properties for nucleus in living cells. A cantilever equipped with a glass needle is approached to a cell in culture solution with an amplified piezoelectric actuator. The deflection indicating the interaction force between a needle and a cell and the approach movement of the cantilever are monitored by laser interferometers with a displacement resolution of 0.08nm. Positioning of a needle to a cell can be observed through an inverse optical microscope. Demonstrated indentation test for a cancer cell of prostate 'gland measured the rapture behavior of the nucleus.
社団法人日本機械学会の論文
2004-09-04