Oxidative Stress, Radiation-Adaptive Responses, and Aging

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概要

• 論文の詳細を見る

• Organisms living in an aerobic environment were forced to evolve effective cellular strategies to detoxify reactive oxygen species. Besides diverse antioxidant enzymes and compounds, DNA repair enzymes, and disassembly systems, which remove damaged proteins, regulation systems that control transcription, translation, and activation have also been developed. The adaptive responses, especially those to radiation, are defensive regulation mechanisms by which oxidative stress (conditioning irradiation) elicits a response against damage because of subsequent stress (challenging irradiation). Although many researchers have investigated these molecular mechanisms, they remain obscure because of their complex signaling pathways and the involvement of various proteins. This article reviews the factors concerned with radiation-adaptive response, the signaling pathways activated by conditioning irradiation, and the effects of aging on radiation-adaptive response. The proteomics approach is also introduced, which is a useful method for studying stress response in cells.

• 日本放射線影響学会の論文
• 2004-10-10

著者

• Miura Yuri

  Redox Regulation Res. Tokyo Metropolitan Inst. Gerontology

• Miura Yuri

  Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology

関連論文

• 139 Proteome analysis of protein expression caused by hydroperoxide or radiation(Redox regulation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Models for Mixed Irradiation with a 'Reciprocal-Time' Pattern of the Repair Function
• Change in Protein Expression by the Slight Oxidative Stress and the Effects of Aging
• Cell Response and Gene Expression due to the Slight Oxidative Stress in Cultured Glial Cells
• Low-Dose Radiation Response of Cultured Glial Cells
• Oxidative Stress, Radiation-Adaptive Responses, and Aging
• Radiation Adaptive Response of Glial Cells

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