ラットの脳における c-fos 発現に対する歯科的侵害刺激の影響
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概要
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ラットの脳における前早期遺伝子c-fos発現に対する歯科的侵害刺激の影響を, Fosに対する免疫組織化学を実施することにより調べた.Pentobarbital麻酔下で, 実験群ラットの第一臼歯を片側性(左側)に抜去した.実験群のラットでは, 抜歯により, 視床の室傍核の前後部, 視床下部室傍核および中脳のEdinger-West-phal核において, Fos免疫陽性ニューロンに有意の増加が認められた.両側の視床下部室傍核において, Fos免疫陽性ニューロンの数に左右差は認められなかった.これらの結果から, 歯科的侵害刺激は, 痛みの感覚伝導路以外に位置する多くのニューロンで, c-fos発現に対する影響のあることが示唆された.
著者
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中川 浩一
Department of Dermatology, Osaka City University Medical School
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中川 浩一
大阪大学歯学部歯科矯正学講座
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YAMASHIRO Takashi
Department of Applied Chemistry, Faculty of Engineering, Hiroshima University
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TAKADA Kenji
Department of Applied Physics Osaka University
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MORIYAMA Hiroshi
Department of Chemistry, Faculty of Science, Toho University
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Moriyama Hiroshi
Department Of Chemistry Faculty Of Science Toho University
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Yamashiro Takashi
Department Of Orthodontics Faculty Of Dentistry Osaka University
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中川 浩一
大阪大学歯学部歯科矯正学教室
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SATOH Keiji
Department of Neuroanatomy, Osaka Medical School
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Yamashiro Takashi
Department Of Applied Chemistry Faculty Of Engineering Hiroshima University
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中川 浩一
Aoyama Gakuin Univ. Tokyo Jpn
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Satoh Keiji
Department Of Anesthesiology Shimane Medical University
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Moriyama Hiroshi
Department Of Orthodontics Faculty Of Dentistry Osaka University
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中川 浩一
Department Of Dermatology Osaka City University Medical School
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Takada Kenji
Department Of Orthodontics Faculty Of Dentistry Osaka University
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