上皮小体摘出ラットの有郭乳頭上皮および神経線維の免疫組織化学的研究
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概要
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To clarify the effects of parathyroidectomy on nerve fibers by decreasing serum calcium levels and epithelial cells in vallate papilla. The quantitative image analysis of immunoreactive nerve fibers and proliferating epithelial cells in the vallate papilla of parathyroidectomized rats was carried out using a CAS 200 image analyzer (CAS). Wistar rats aged 6 to 11 weeks were used in this study. Antibodies against the protein gene product 9.5 (PGP), calcitonin generelated peptide (CGRP), and substance P (SP) were used for the analysis of the nerve fibers, while an antibody against the proliferating cell nuclear antigen (PCNA) was used for analyzing the proliferating ability of the trench epithelial cells. The results were summarized as follows. 1. In the control group, the percentages of PCNA, PGP, CGRP, and SP immunoreactive areas of 6-week-old rats were found to be significantly higher than those of 8-week-old and older rats. 2. The administration of activated vitamin D_3 to parathyroidectomized rats was effective in recovering the proliferating ability of trench epithelial cell, and in recovering PGP, CGRP, and SP immunoreactive nerve fibers. 3. There was a close correlation between the total Ca concentration in sera with PCNA immunoreactive cells, PGP, CGRP and SP immunoreactive nerve fibers in the trench epithelia. 4. CGRP and SP immunoreactive nerve fibers have an effect on the epithelia in the vallate papilla. These results suggest that CGRP and SP containing nerve fibers in the trench epithelia effect the function and shape of the epithelia in vallate papilla. They also suggest that CGRP containing nerve fibers can also effect the maintenance of blood vessels in the vallate papilla.
- 福岡歯科大学学会の論文
- 2000-03-31
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