Aggrecanases in Cartilage Matrix Breakdown

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概要

• 論文の詳細を見る

• In rheumatoid arthritis and osteoarthritis, the loss of extracellular matrix macromolecules, aggrecan and collagens exceeds new production, resulting in serious joint impairment. The primary cause of this loss is due to elevated proteolytic enzyme activities. Recent studies have suggested that the enzymes called 'aggrecanases' that specifically cleaves the Glu^<373>-Ala^<374> of the aggrecan core protein play a key role in the early phase of cartilage destruction. Two aggrecanases have been purified and cloned, they are designated as ADAM-TS4 and ADAM-TS5, subfamily members of the ADAM family. Recombinant ADAM-TS4 and ADAM-TS5 effectively cleave the core protein of native aggrecan, but they have little action on other protein substrates.

• 日本結合組織学会の論文
• 2001-03-25

著者

• Nagase Hideaki

  The Kennedy Institute Of Rheumatology Division Imperial College School Of Medicine

関連論文

• Aggrecanases in Cartilage Matrix Breakdown
• Imbalance between Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloproteinases 1 Expression by Tumor Cells Implicated in Liver Metastasis from Colorectal Carcinoma.

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