半月板の修復のバイオロジー(<特集>骨関節領域における結合組織研究の進歩)

概要

論文の詳細を見る
Meniscus is one of the cartilaginous tissues in the knee joints which plays important roles in joint motion, load transmission or lubrication. It is well known that intrinsic healing of injuredmeniscus is limited even if repaired surgically, and that degenerative joint disease develops following loss of its function. We investigated human and rat meniscus cells in the primary culture to characterize their potential of proliferation and gene expression of matrix proteins (type I, II, III, IX collagens and aggrecan), growth factors (TGF-β1, FGF-2, PDGF-A, IGF-II), and their receptors (TGF-βRI, FGFR1, PDGF-R, IFG-I-R). Furthermore, we studied the effect of these growth factors on cell proliferation. Finally, we investigated the possibility of meniscus transplantation with autogenous meniscus cells. Rat meniscus transplantation model was developed and collagen scaffold was used for meniscus cell seeding. These experiments showed future feasible strategy of meniscus cell therapy for meniscus injuries.
日本結合組織学会の論文
2000-09-25