New Horizons in Tissue Engineering:Connective Tissue Research(Special Issue on "Adrances in Connective Tissue Research in dentistry")

概要

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Tissue engineering, a medical application of biotechnology, depends largely on the maintenance of consistent cellular phenotype and vitality. One of the challenges in biotechnology is that the health and productivity of the floating cells is often not optimal, even in the most sophisticated bioreactors. Many living organisms and cells cannot thrive without attaching to a scaffold, Which plays a key role in cell-matrix interaction and transmission of mechanical stress. The extracellular matrix(ECM)scaffolds found in nature possess a unique set of protein components and three-dimensional structure specific to the surrounding tissue. Connective tissue research on ECM components and structures has produced a large volume of information in the past decade, Which may serve in the design of dynamic bio-scaffolds. New dynamic bioscaffolds with various mechanical properties can be used to advance our fundamental understanding of how cells react to applied mechanical strain and provide the basis for designing biomaterials for tissue engineering. The objective of this review is to explore a possible research and development strategy for the design of such new biomimetic dynamic bio-scaffolds.
日本結合組織学会の論文
2000-03-25