上顎側方拡大後の縫合部修復過程におけるDNA担体b-FGFの効果
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The present study examined the effects of DNA carrier b-FGF on tissue restoration in orthodontically expanded midpalatal sutures in rats. One hundred and sixty male Spraque-Dawley rats were used. Maxillary expansion was continued for 2days, followed by 1, 3, 5 or 7 days of retention. Animals were divided into 4groups. The following solutions were injected in to the midpalatal suture areas at the end of the expansion procedure: 10μl physiological saline for the control group; 10μl DNA solution (50μg/10μl) for the DNA group; 10μl b-FGF solution (5μg/10μl) for the FGF group; and DNA carrier b-FGF solution (5μg b-FGF and 50μg DNA/10μl) for the experimental group. After retention, specimens were produced and Hematoxyline-Eosin stain, van Gieson stain, and immunostaining using Proliferating Cell Nuclear Antigen (PCNA) antibody were performed. The experimental group demonstrated an active osteogenesis after the 3rd day of retention and a higher rate of osteogenesis than all of the other groups on the 7th day of retention. The number of PCNA positive cells continued to increase from the 3rd to the 7th day of retention in the experimental group, whereas the numbers decreased from the 5th to the 7th day of retention in the FGF group. These results suggest that the DNA carrier b-FGF continuously accelerates the tissue restoration process in orthodontically expanded sutures.
- 福岡歯科大学学会の論文
- 2002-12-31
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