馬の伝染性貧血症における赤血球自己抗体の性状とその役割

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概要

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• In the recent years, various red cell auto-antibodies have been determined in someanimal diseases, including autoimmune hemolytic anemia and systemic lupus erythe-matosus in dogs,") Aleutian disease in minks,8) and equine infectious anemia."?">In this report, the red cell auto-antibodies were examined for symptomatiCchanges, serological characteristics, and immunopathological roles in 20 horses infectedwith equine infectious anemia virus (Table l).Pathologic cold hemagglutiuain and warm hemagglutinin were identified in theplasma of artificially infected horses. The direct antiglobulin tests of red cells gavealso positive results, showing an intimate correlation with the appearance of warmhemagglutinin, in infected horses of febrile stage (Chart l and Table l). Red cellsin the portal veins of the liver tissue were always higher in titer in the antiglobulintests than those in the jugular veins. There was an intimate correlation between thistiter and the number of red cells in the jugular vein of the infected horses (Table 2).Both warm and cold hemagglutinins were macroglobulins (IglVI) which were inn-activated with 2-mercaptoethanol, and found in the first peak of the plasma proteinfractions obtained by get filtration using Sephadex G-200 (Chart 2). These auto-hemagglutinins reacted with horse red cells, but did not with red cells of any otheranimal species, such as sheep, rabbit, guinea pig, or chicken. In tl?e pattern ofreaction between warm hemagglutinin and horse red cells, prozones were formed byexcess antigen or antibody (Table 3) . The auto-antibodies, combined with the redcells of the infected horses and correlated with the antiglobulin test, were serologicallydetermined to be composed predominantly of IgM, like warm hemagglutinin, andprobably partially of IgG (Table 4 and Fig. l).Warm hemagglutinin among these red cell auto-antibodies exhibited 2L1l opsonicaction but no hemolytic action, and accelerated phagocytosis of horse red cells bymacrophages (Figs. 3, 4, and 5).It was considered that the presence

• 社団法人日本獣医学会の論文
• 1970-10-25

著者

• 三浦 克洋

  東北大学農学部家畜衛生学教室

• 大木 与志雄

  農林省家畜衛生試験場研究第3部

• 大木 与志雄

  農林省家畜衛生試験場

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