蚊アレルギーからHEN病へ

概要

論文の詳細を見る
"Mosquito allergy" is a unique disease characterized by intense local skin symptoms and high fever following mosquito bites, which was reported in Japan in 1969 for the first time. At first, the unique symptoms of this disease were at-tractive to many physicians and immunologists. Thereafter, since many cases had been accumulated, the fact that most of the patients with "mosquito allergy" had died of hematological malignancies, such as malignant histiocytosis, malignant lymphoma and leukemia, with the years appeared in 1980s. We were interested in this disease from the virological and hematological point of view. Through the collaborative studies of 5 cases, we proved that "mosquito allergy" was the primary manifestation of Epstein-Barr virus (EBV)-associated natural killer (NK) cell leukemia /lymphoma in the end of 1990s. As "mosquito allergy" is not an allergic disease, it have been called hypersensitivity to mosquito bites (HMB). Then we proposed HMB-EBV-NK (HEN) disease as one of EBV-associated lymphoproliferative diseases in order to find the patients who would suffer from hematological malignancies in the early stage of their disease.
日本衛生動物学会の論文
2004-03-15