ニトログリコール中毒の臨床的研究
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概要
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Since 1959 there have been four fatal, eight non-fatal, and twelve suspective cases of nitroglycol poisoning among workers in the plant to which author's hospital belongs. Of the fatal cases, two engaged in press-extending work, one in packing aged between 35 and 50, employed for 12 to 22 years. Of 27 stenocardiac paroxysms in all, 18 occured 36 to 60 hours after cessation of works and in the eary morning in most of them, preferring summer season to others. The duration of the fit were between 20 and 40 minutes. Main symptoms of the fit were acute general debility, pressure or suffocating feeling and pain in the chest, acceleration of pulse rate, and fainting. In the non-fatal cases, the process of recovery was prompt and the workers could resume the daily work as usual. Nitroglycerine was ineffective for treatment as well as for prevention of the fit, while ATP seemed to be somewhat effective for prevention. As to ECG no special finding was confirmed except atrial fibrillation in one case. On necropsies of two cases, slight hypertrophia of the left ventricle, minor sclerophia of the left ventricle, minor sclerosis of the coronary arteries, edema and transversal bands in the heart muscle, decrease of lipoids content in the adrenals, and inflammatory findings in the kidneys were observed. Although findings peculiar to the nitroglycol poisoning by tests and measurements were not confirmed in all the cases, the time relation of the occurrence of the fit to nitroglycol exposure, its duration, and its symptome made it very probable to be due to the nitoroglycol poisoning. This causal relation were made more probable by the correlations of the length of employment and the following items. That is to say, higher diastolic blood pressures at rest, decrease of the increment of systolic blood pressures on the attack of fit, decreased counts of erythrocytes, leucocytes, and eosinophils, decrease of the increment of the blood sugar level by food intake, decrease of the ratio albumin/globulin of the blood serum, increase of the concentrating capacity of the kidneys, increase of the increment of the blood pressure by adrenaline injection, all of these were marked in the employees over ten years of employment. The author discussed also the mechanism of the attack of paroxysm due to nitroglycol poisoning.
- 社団法人日本産業衛生学会の論文
- 1962-10-20