CS_2の代謝に関する研究 : グルタミン酸とCS_2との化合物の代謝

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Concerning CS_2 metabolism in the body, the balance sheet of inhaled and excreted CS_2, and also the end products of its metabolism excreted in the urine have to some extent been made clear. Intermediate change of CS_2, however, is not yet well known except chemical combination of CS_2 with protein and α-amino-acid. In this report, metabolism of compounds of CS_2 with protein or amino-acids was studied in rabbits by a method of determining the amount of reversibly combined CS_2 Compounds of CS_2 with protein or amino-acid have a characteristic nature of liberating free CS_2, when pH of the solution of these compounds is adjusted to 2 or less. Therefore, the amount of free CS_2 liberated by adjustment of pH is a measure of reversibly combined CS_2. The results obtained are as follows. 1. In the fluid media of liver, kidney and brain slices to which CS_2 was added, sulfate was not demonstrated to increase when compared with the control. 2. In the course of 1.5 hours following subcutaneous injection of CS_2, reversible free CS_2 was not proved to exist in the blood of rabbits. Accordingly, compounds of CS_2 with protein or amino-acid may not be retained as such in the body. 3. When compounds of CS_2 with glutamic acid (CS_2-G) or with diethylamine (CS_2-D) were injected into the rabbit, these were not detected in the blood in 1.5 hours after the injection. Thus CS_2-G or CS_2-D was considered to change readily into other forms. 4. CS_2-G compound was considered to react with some constituents of the blood, since CS_2-G added to the hemolyzed blood solution could not be recovered. 5. It was revealed that CS_2-G reacted with hemoglobin forming some compounds which do not liberate free CS_2, when pH of the reaction medium was adjusted to 2 or less. 6. Moderately diluted serum in saline solution did not seem to react with CS_2-G, whereas larger volume of such solution reacted with CS_2-G. 7. Tyrode's solution or glutathione solution was not found to react with CS_2-G.
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CS_2の代謝に関する研究 : グルタミン酸とCS_2との化合物の代謝

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