SO_2 ガス吸入の肺換気機能に及ぼす影響について

概要

論文の詳細を見る
Forty six healthy males were subjected to the inhalation of SO_2 gas of 1∼45 ppm for 10 min. through a mask from high efficiency gas chamber, and changes of clinical symptoms, respiration rate, pulse rate, vital capacity, 0.5 sec. expiratory capacity, Wright's expiratory peak flow rate were measured. The results obtained are summarized as follows: 1) The subjects did not complain any symptoms except few persons when they inhaled of 1∼5 ppm SO_2 gas. When exposed to 10∼30 ppm all subjects experienced a sense of burning of the upper respiratory tract, cough, chest-tightness, and in several persons moist rales in the chest were heard. 2) A slight increase of pulse and respiration rates was observed in about 10 percent of the subjects with no proportionate ralation to the concentration of SO_2. 3) The 0.5 sec. expiratory capacity and Wright's peak flow rate showed a liner decrease in proportion to the increase of SO_2 concentration, i.e. a decrease by 10 percent in 10 ppm and by 15 percent in 40 ppm. It was striking that vital capacity was observed to be constant. The lowest limit of SO_2 concentration which induced the bronch-consntriction was about 1.6 ppm. Within 10 min. after the inhalation the physiological changes returned to the preexperimental level. 4) When SO_2 of 15-41 ppm was inhaled several times for 10 minutes, the bronchial response tended to lessen in the grade and the subjects seemed to be accustomed to SO_2. 5) When the subjects inhaled broncho-dilator (Isoproterenol Hydrochloride) aerosols the constriction of brochus result from SO_2 was immediately released and no constriction by repeated SO_2 inhalation occured.
社団法人日本産業衛生学会の論文

SO_2 ガス吸入の肺換気機能に及ぼす影響について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク