高熱作業者の疲労に対するTTFD錠の効果について : 二重盲検比較対照試験による検討

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In an attempt to objectively investigate the effect of TTFD (Thiamine Tetrahydrofurfuryl Disulfide) on fatigue of workers in high temperature environments in an iron works, a double-blind comparative study was made in summer, 1969. The experiment was designed on the basis of the results of a preliminary investigation carried out about one month before. The drugs used in the study were F25 tablets containing 25 mg of TTFD each and F50 tablets containing 50mg of TTFD each. These drugs and the placebo were used in the form of similar sugarcoated tablets which could not outwardly be distinguished. The workers were divided into two groups: one being administered F25 or placebo, the other F50 or placebo, and thus the crossover study was accomplished. Allocation was performed at random. In both the first term and the second term, the drug was administered for ten days, one tablet daily just before work and washout was carried out with the placebo for five days prior to each term of the administration. Fatigue was examined in terms of the flicker test, and in ten check items each of A and C of "Fatigue Scale of the Industrial Fatigue Research Committee of Japan Association of Industrial Health". The condition of fatigue was also examined according to five-graded score in order to investigate the relationship between the feeling of fatigue of workers and the characteristic values obtained in the examination. For both the first term and the second term, the examination was performed daily for eight days before and after work. By the use of the characteristic values obtained in the examination as described above the effect of the drugs was analyzed for the same subjects who worked at each comparison time of 1, 2 or 3; the data in the period during which F25 was given being compared with those in the period during which the placebo was given, and the data in the period during which F50 was given with those in the period during which the placebo was given. The conclusions thus reached are as follows: 1. The flicker test values obtained after work were higher when TTFD was given than when the placebo was given, with a statistically significant difference. In comparison of F25 with F50, the estimated effect of F50 was greater than that of F25. 2. In the analysis of the number of items complained out of the Fatigue Scale A, C and A+C, the number of workers without any subjective fatigue after work was more when F50 was given than when the placebo was given, with a statistically significant difference. 3. Correlations between: a) the condition of fatigue and the flicker test value, b) the condition of fatigue and the number of items complained out of the Fatigue Scale A, c) the condition of fatigue and the number of items complained out of the Fatigue Scale C were calculated in terms of Spearman's rank correlation coefficients and the sign test was carried out. Furthermore, exactly in the same way, the mutual correlations between i) the flicker test value, ii) the number of items out of the Fatigue Scale A, iii) the number of items out of the Fatigue Scale C were also calculated and the sign test was carried out. From the result of the sign test, a statistically positive correlations concerning the degree of fatigue was found between the condition of fatigue, the flicker test value, the number of items of the Fatigue Scale A or C. In other words, it was shown in many cases that when fatigue was indicated by any of the characteristic values, it was indicated by other characteristic values as well.
社団法人日本産業衛生学会の論文
1971-02-20

高熱作業者の疲労に対するTTFD錠の効果について : 二重盲検比較対照試験による検討

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