鉛中毒シロネズミの腎における鉛の貯留について : 組織学的ならびに電子顕微鏡学的考察
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Deposition of lead in the kidney of rats suffered from lead poisoning were examined by the use of both light and electron microscopes. Chronic lead poisoning of rats was attained by 13 successive intraperitoneal injections with 1 ml of 1% lead acetate solution once in two weeks over a period of 26 weeks. Subacute lead poisoning of rats was attained by 3 intraperitoneal injections with 1 ml of 5% lead acetate solution once in two weeks over a period of 6 weeks. Light microscopic observations on the kidneys from chronically lead-poisoned rats showed that proximal tubules were atrophic with a concomitant increase and swelling of the interstitial tissue, or dilatated with flattened and atrophic epithelia. Most glomeruli appeared intact. The presence of dense concretions and nuclear inclusion bodies in the epithelial cells of the proximal tubules was dominant in this case. The dense concretions were different from the inclusion bodies, spherical or ovoid in shape, and varied in size, of which diameter ranged up to 50 μm. In subacutely lead poisoned rats, the concretions usually appeared in the lumen of the proximal tubule. A hydrogen sulfide test for identification of lead by Iwahashi strongly suggested that the concretions contained lead. From the electron microscopic observations, the concretions were shown to be the complexes of needle-like components less than 100 Å in width and electron-dense material. The needle-like component were usually organized into concentric lamellae, on which the dense material deposited. The concretions were never found in nuclei. Besides, the concretions were clearly surrounded by a single membrane. Inclusion bodies were found in the enlarged nuclei of proximal tubule cells as complexes of filament of 70-170 Å in width and electron-dense substance. From these fidings, it was suggested that exogenous lead deposited in the concretions enclosed by the limiting membranes which may be a form of lysosome.
- 社団法人日本産業衛生学会の論文
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