水銀中毒に関する研究 : 第1報農薬として使用される有機水銀の急性経口毒性

概要

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The experiment on the acute oral toxicity of some organic mercury compounds that were available was made to evaluate LD_<50> of each compound. The result was as follows: 1) Acute oral toxicity of several organic mercuric compounds used for pesticide was tested on rats. The oral LD_<50> was strongest for methoxyethylen mercuric chloride, being 26.2 mg/kg, next comes phenyl-mercuric acetate with LD_<50> of 39.5 and then ethylmercuric phosphate (50.8), ethymercuric choride (60), and phenylmercuricp-toluene sulfonic acid (88.9) in the decreasing order. 2) As for the symptoms in the acute poisoning, depression and diarrhea were eminent. Some cases showed bleedings in the peri-oral area. Rats died in prostration, without any sign of tremor or paralysis. 3) Histopathological findings of the kidney were characterized by severe congestion accompanied with nephrosis while in the liver acute inflammatory changes with congestion and fatty degeneration were found. There was found no difference regarding the chemical structures of organic mercuric compounds tested in this experiment.
社団法人日本産業衛生学会の論文
1964-09-20