軽症二硫化炭素中毒に関する研究 : 某セロファン製造工場の実態調査から

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Medical examinations of the workers exposed to carbon disulfide in a cellophane factory were made, and the results obtained were analysed. The examinations consist of hematological examinations (erythrocyte count, hemoglobin content, reticulocyte count and the ratio of neutrophilic leucocyte count to lymphocyte count-N/L), liver function tests (urobilinogen in urine, Millon's reaction of urine, Takata's reaction of serum, cephaline cholesterol test of serm and the ratio of albumin to globilin in serum-A/G), measurements of blood pressure (upper arm and eye), ophthalmologic examinations (examinations of visual field and retina), adrenocortical function tests (17-OHCS and 17-KS in urine) and other examination (total glucuronic acid, glucuronic acid of glucoside type and creatinine in urine). The results obtained are as follows: 1) The group exposed to carbon disulfide showed higher abnormal findings in almost all items of examinations than the control group of unexposed workers, and there were significant differences between the two groups on the following symptoms, namely fall in N/L in blood picture, narrowing of the visual fields (especially colour visual field), increase of urobilinogen in urine, fall in A/G of serunm, decrease of 17-OHCS and 17-KS in urine, decrease of glucuron acid and glucuronic acid of glucoside type in urine and increase of creatinine in urine. Besides,anemia, increase of reticulocyte count, some findings in retina and rise of blood pressure were found in low grade. 2) Coeffcients of correlation between two of the following symptoms specially noticed in this examination were calculated; N/L in blood picture, liver function, blood presssure, visual field, retina findings adrenocortical function and creatinine in urine. And, there were statistically significant correlations at 1% level between two of the following three symptoms, impairment of adrencortical function, impairment of liver function, and fall in N/L in blood picture; also between impairment of adrenocortical function and constriction of the visual fields. But there were nocorrelations in other combinations of the above symptoms. These results shows that in mildcarbon disulfide poisoning symptoms appearing in each worker are considerablly varied. Therefore, for early detection of carbon disulfide poisoning, it is to be desired that many kinds of examinations as mentioned above are taken. 3) The group exposed to carbon disulfid showed wider standard deviations in values obtained in almost all examinations than the control group. This is due to the fact that in the group exposed to carbon disulfide there are some poisoned people mixed in healthy men, and it seems that this is not specific and found not only in workers exposed to carbon disulfide, but non-specific and generally found in workers exposed to some kind of poisons. Some workers of the group exposed to carbon disulfide showed rather higher level of adrenocortical function than the control group. Thus, the carbon disulfide is supposed to act as a kind of stressor causing elevated adrenocortical function.
社団法人日本産業衛生学会の論文

軽症二硫化炭素中毒に関する研究 : 某セロファン製造工場の実態調査から

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