血液中水銀についての研究
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In order to clarify the behaviour of mercury in the blood, a mixture of ^<203>HgCL_2 with human blood was prepared, and the distribution of mercury in the blood components and the state of mercury bound with blood corpuscles and with plasma protein were studied. The main results obtained are presented hereunder: 1) Distribution of mercury in the blood components: When the addition of ^<203>Hg to the whole blood has been at a concentration of 10^<-3>M, more mercury is present in the blood corpuscle fraction than in the plasma fraction, and vice versa at lower concentrations than 10^<-3>M. The lower the concentration of mercury added, the less is the mercury present in the blood corpuscle fraction. 2) Mercury in the blood corpuscle fraction: The majority of the mercury is bound so weakly with blood corpuscles as to be readily removed from them on being washed with physiological saline solution. As a part of the mercury, however, can not be removed from the corpuscles on washing with Ca-EDTA solution instead of the saline, some amount of mercury may be strongly bound with blood corpuscles. 3) Mercury in the plasma fraction: Mercury in the plasma fraction is not bound with plasma protein and seems to be merely dissolved in the plasma fraction. 4) In vivo experiment: When the intravenous administration of mercury was done to the rabbits, the mercury in the blood decreased rapidly and the portion of mercury was more in the blood plasma than in corpuscles.
- 社団法人日本産業衛生学会の論文
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