カドミウム中毒に対するCa-EDTAの作用 (II) : 尿中カドミウム等に対するCa-EDTAの作用

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One of the authors had previously proved in the experimental study on lethal time of mice that Ca-EDTA provided some protective effect against the toxicity of cadmium. In this paper the authors attempt to clarify whether the drug, Ca-EDTA, could accelerate the urinary excretion of cadmium. The first experiment (A): 6 rabbits were injected subcutaneously with 3.37 mg of CdCl_2 every other day for 12 days. Three of the animals were given subcutaneously, one hour after the injection of CdCl_2, 141 mg of Ca-EDTA in 10 ml of 5% glucose solution. The remaining animals were set aside as controls and received only glucose treatment. Laboratory examinations were done on blood; erythrocyte and leucocyte count, hemoglobin content and serum protein content, and on urine; coproporphiline- and urobilinogentest. Cadmium content in urine as well as in organ tissues were measured polarographically. The second experiment (B): 10 rabbits were injected with 6.74 mg of CdCl_2 a day for three days and then with the same dose every other day for 14 days. After the last injection the animals were divided into two groups of 5 rabbits each. The animal of one group was administered 268.68 mg of Ca-EDTA in the same way as in (A) for 5 days. The other group served as controls and received only glucose treatment. The items examined in this experiment were, including those in (A), hematocrit value, blood specific gravity, and reti culocyte count. The third experiment (C): 6 rabbits were injected with radioactive cadmium in 1 ml of 0.34%-Cd^*(NO_3)_2, and one hour after the injection 3 of the animals were given 500 mg of Ca-EDTA and the remaining animals served as controls and received no treatment. The cadmium in 24 hour urine specimens was measured by the use of a scintillation counter. In this experiment cadmium content of every fraction of serum protein was determined by paperelectrophoresis. The results obtained were the followings: In the experiment (A): 1) Cadmium could not be detectable in the urine during the whole experimental period, but it appeard in a trial in which Ca-EDTA was given intravenously at the end of the experiment. 2) Cadmium content in liver and in kidney was slighter in a group administered with Ca-EDTA than in the organ tissue of the controls. 3) There were no other marked findings between the both groups. In the experiment (B): 1) Cadmium produced anaemia, such as a decrease of erythrocytes, hemoglobin content and hematcrit value. Ca-EDTA could not arrest these symptoms. 2) Ca-EDTA accelerated to some extent the urinary excretion of cadmium. 3) Cadmium content of the organ tissues showed no significant difference between the two groups. In the experiment (C): 1) Cadmium content in the urine sample was much larger in the animals administered with Ca-EDTA than that of the controls. 2) Cadmium content in the serum was diminished by Ca-EDTA. 3) The authors could not recognize a marked difference of cadmium content in every fraction of the serum protein.
社団法人日本産業衛生学会の論文

カドミウム中毒に対するCa-EDTAの作用 (II) : 尿中カドミウム等に対するCa-EDTAの作用

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