Assessment of Peripheral, Central and Autonomic Nervous System Functions in Two Lead Smelters with High Blood Lead Concentrations : A Follow-Up Study
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概要
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Assessment of Perpiheral, Central and Autonomic Nervous System Functions in Two Lead Smelters with High Blood Lead Concentrations : A Follow-Up Study : Yasushi FUJIMURA, et al. Department of Public Health, School of Medicine, University of Tokyo-To examine the effects of lead on peripheral, central and autonomic nervous system functions, the median and radial motor and sensory nerve conduction velocities (MCV and SCV), distribution of median nerve conduction velocities (DCV), short-latency somatosensory, brainstem auditory and visual evoked potentials (SSEP, BAEP and VEP, respectively), event-related potential (P300), and electrocardiographic R-R interval variability(CV_<RR>)were measured once a manth for 12 and 25 months in two male lead smelters with the first blood lead(BPb) concentrarions of 105.6 μg/d/(Lead smelter 1) and 76.5μg/d/(Lead smelter 2), respectively. The measurements were conducted a day before the workers underwent BPb measurement and lead mobilization test with 1-hr calcium disodium ethylenediamine tetraaceteta infusion. The following results were obtained: (1) The delayed values for V20-V90 velocities of the DCV, MCVs in the median and radial nerves, SCV in the median nerve, N13-N20 interpeak latency of the SSEP, V latency of the BAEP, and P300 latency in Lead smelter 1 were significantly more frequent than the expected values in control subjects. (2) Also, the delayed values for V60-V90 velocities of the DCV, MCV and SCV in the median nerve, and N9 latency of the SSEP in Lead smelter 2 were significantly more frequent that the expected values in control subjects. (3) The delayed values for MCVs in the median and radial nerves and N13-N20 interpeak (SSEP), V(BAEP) and P300latencies in Lead smelter 1 were significantly more frequent than those in Lead smelter 2. (4) In the two lead smelters, the delayed values for V80 and V90 velocities of the DCV were significantly more frequent than those for V10 and V20 velocities. These data suggest that faster nerve fibres of the peripheral nerve are more sensitive to chronic lead exposure than slower nerve fibres are, and peripheral nerve funtion is more sensitいve to chronic lead exposure than central and autonomic nervous system functions.
著者
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ARAKI Shunichi
Department of Internal Medicine, Yokosuka Kyosai Hospital, 1-16,Yonegahama-dori, Yokosuka-City, Kana
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Araki S
National Inst. Industrial Health Kanagawa Jpn
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Araki Shunichi
Department Of Public Health Faculty Of Medicine University Of Tokyo
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MURATA Katsuyuki
Department of Environmental Health Sciences, Akita University School of Medicine
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SAKAI Tadashi
Center of Occupational Medicine, Tokyo Labor Accident Hospital
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Murata K
Univ. Tokyo Tokyo Jpn
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Sakai Tadashi
Center Of Occupational Medicine Tokyo Labour Accident Hospital
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FUJIMURA Yasushi
Department of Public Health, School of Medicine, University of Tokyo
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Murata Katsuyuki
Department Of Environmental Health Sciences Akita University Graduate School Of Medicine
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Araki Shunichi
National Institute Of Occupational Safety And Health
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Fujimura Yasushi
Department Of Public Health School Of Medicine University Of Tokyo
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Araki Shunichi
Department Of Central Laboratory Tokyo University Hospital 7-3-1 Hongo Bunkyo-ku Tokyo 113 Japan
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Fugimura Yasushi
Department of Public Health, School of Medicine, University of Tokyo
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