Nordihydroguaiaretic acid effects on the metabolism of mung bean mitochondria

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概要

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• Nordihydroguaiaretic acid (NDGA) from plant creosote bush (Larrea divaricata. L.) stimulates respiration of mung bean mitochondria with all respiratory substrates examined. Maximum respiratory stimulation occurred with externally added NADH where rates were over twice state IV rates (6), with a half maximal stimulation occurring at 72 μM. With the substrates pyruvate and malate, NDGA produced a half maximal stimulation at 25 μM, while succinate respiration was first slightly inhibited before being stimulated. With all substrates high concentrations of NDGA partially inhibited respiration. Concentrations of NDGA which produced maximum respiratory stimulation caused a reduction in P : O rates of 45% with succinate, 33% with NADH and 30% with malate plus pyruvate. While respiratory and coupling response of mung bean mitochondria to NDGA are qualitatively similar to those reported with the classical uncoupler, 2,4-dinitrophenol, they are quantitatively less and generally occur at higher concentrations.

• 日本植物生理学会の論文

著者

• Scharff Milton

  The University Of Texas Medical School

• Wilson R.

  Monsanto Company

関連論文

• Nordihydroguaiaretic acid effects on the metabolism of mung bean mitochondria

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