Metabolic responses to lycorine in plants

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Lycorine, an alkaloid found in Amarillidaceae, inhibits growth in higher plants and in yeasts. Lycorine-treated pea internodes, Avena coleoptiles and yeasts revealed a decrease in the amount of both ^<14>C-leucine incorporated into protein and ^3H-uridine incorporated into RNA. The time course of these incorporations, however, shows that the drop in ^<14>C-leucine incorporated into protein appears prior to any inhibitory effect of ^3H-uridine incorporation into RNA. Moreover, in lycorine-treated plants, the ascorbic acid/dehydroascorbic acid ratio is lowered. Nevertheless, our data seem to indicate that this latter effect becomes evident later than the inhibition of ^<14>C-leucine incorporation into protein. In vitro experiments with a cell-free system showed no inhibitory effect by lycorine on elongation of the polypeptide chain when yeast ribosomes were used. At this point in our experimental work, we would venture to suggest that lycorine might affect plant growth by inhibiting protein synthesis at some step which is not, however, the elongation of the polypeptide chain.
日本植物生理学会の論文