新脳血管拡張薬マレイン酸シネパチドと水との相互作用

概要

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Hydration of cinepazide maleate (DD-3357), a vasodilate agent, has been examined by means of solubility test and moisture equilibrium test. Consequently, it was clarified that DD-3357 was converted into a stable dihydrate (DD-3357・2H_2O) in water and/or under higher humidity conditions, and that the driving force for the conversion was ascribed to the enthalpy change, ΔH_<A, H>=-5.5 kcal/mol for the hydration reaction. On the other hand, the dehydration reaction of DD-3357・2H_2O was investigated by means of thermal analysis. Kinetic analysis of the TG curve indicated that the dehydration reaction followed the first-order rate reaction with an activation energy of 29.0 kcal/mol. The heat of dehydration reaction was also discussed using the results from DSC.
公益社団法人日本薬学会の論文
1983-01-25