イソニアジドおよびその関連化合物の安定性(第3報) : イソニアジドの嫌気的酸分解

概要

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Anaerobic acid decomposition of isonicotinic acid hydrazide (INAH) was examined in the range of pH 3.1 to Ho-2.84,where INAH is present in dication type, monocation type, and nondissociated type. In the initial stage of the reaction, INAH undergoes decomposition by the pseudo-first order reaction to form isonicotinic acid. Examination of the ω value proposed by Bunnet showed that in strongly acid solution adjusted with perchloric acid, six moles of water seem to take part in the decomposition of the dication-type INAH. Decomposition in the pH range of 1.20〜3.10,using phosphate or oxalate buffer, showed the effect of acid-base catalyst due to the component of the buffer used. Acid dissociation constant of INAH suggested the present of dissociated type INAH over the whole range of pH examined. Primary salt effect was almost negligible at 37° but was found at 70°. Activation energy for the decomposition of the dication-type INAH was calculated as 23.9kcal./mole.
公益社団法人日本薬学会の論文
1967-08-25