Glucuronosideの加水分解に関する研究(第2報) : β-D-Glucopyranosiduronic AcidのAglyconeが酸加水分解速度に与える影響

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概要

• 論文の詳細を見る

• Effect of the electron affinity of the aglycone group in the rate of acid hydrolysis of alkyl-β-D-glucopyranosiduronic acid was examined. Electron-attracting aglycone was found to decrease the acid hydrolysis rate greatly, while the electron releasing aglycone greatly increased the rate. The Hammet-Taft rule was applied to the acid hydrolysis rate of glucopyranosiduronic acid and glucopyranoside, and the result suggested that the mechanism of hydrolysis was the same for glucopyranosiduronic acid (ρ^*) and for glucopyranoside (ρ_1^*) having an electron releasing aglycone, but differed from that of glycopyranoside(ρ_2^*)having an electron-attracting aglycone. The activation energy has the greatest effect on the acid hydrolysis rate constant of glucopyranosiduronic acid and the entropy of activation has no part in it.

• 公益社団法人日本薬学会の論文
• 1967-05-25

著者

• 富田 栄一

  中外製薬株式会社総合研究所

関連論文

• Glucuronosideの加水分解に関する研究(第4報) : Glucofuranosidurono-3,6-lactoneとGlucopyranosiduronic Acidおよびそれらのα-, β-Anomerの酸およびアルカリによる加水分解
• Glucuronosideの加水分解に関する研究(第3報) : β-D-Glucopyranosiduronic Acidのアルカリ分解
• Glucuronosideの加水分解に関する研究(第2報) : β-D-Glucopyranosiduronic AcidのAglyconeが酸加水分解速度に与える影響
• Glucuronosideの加水分解に関する研究(第1報) : β-D-Glucopyranosiduronic Acidの酸触媒反応
• Studies on Oxidized Starch Sulfates for Medical Purposes. I. Synthesis of Sulfates of Oxidized Starch and its Derivatives.

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