炭水化物のTransformationに関する研究(第2報)グルコースの希強アルカリ性溶液中における変換反応と分解反応その1

概要

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In diluted NaOH solution at 30°, glucose epimerized to fructose and mannose, and degraded to arabinose. Small amounts of ribulose, ribose and erythrose were also found in the degradation products. The degradation was affected by the concentration and volume of NaOH solution. When 2 mg of glucose was dissolved in 40 ml of 0.25 N NaOH, the yield of arabinose reached the maximum. Purity of the reaction solvent (water) had an effect on the yield of arabinose and therefore it was assumed that there were some catalyses by trace amounts of unidentified substance in water on the degradation. When Ba(OH)_2 solution was used in place of NaOH solution, glucose was rather decomposed to non-carbohydrates. Utilization of the metabolic degradation of hexoses by commercial baket's yeast made a quantitative analysis of arabinose on the liquid chromatogram possible. Quantitation was accomplished by integrating the area under the peak using the height-width method, and it was found that 3.7% of glucose in 0.25 N NaOH solution degraded to arabinose after 27 hr. Autoradiogram of the transformation products from ^<14>C-labeled glucose in 0.25 N NaOH solution indicated that the carbon in 1-position was split off to give arabinose.
公益社団法人日本薬学会の論文
1974-02-25