粉粒体の凝集性(第3報)粒子形態の影響

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概要

• 論文の詳細を見る

• Influence of partic1e shape on cohesiveness of partic1es was studied. Experiments were made using the cylindrical particles such as vermicelli and copper wire having different diameter and length. The apparatus and procedures reported in the previous paper were used for cohesion measurement. The samples used were considered to have no diffence in their size and shape, and to have a geometrical shape, and seem to be convenient for determination of the shape factor (ψ). For simplification ; the ratio of d_l to d_o was used as a shape factor, where d_l is the diameter of the sphere inscribed with the particle and d_o is that of the one circumscribed with the particle. The effects of particle diameter (φ), length (l), and shape factor (ψ) on cohesive force (f_e), and the apparent cohesiveness (α_e) were shown experimentally. The relationship between f_e and l gave almost a straight line, but f_e and φ did not. This difference may be attributed to the difference in particle weight and the degree of leaning between particles which was represented as leaning efficiency (P) previously. The α_e decreases with increase in particle diameter, and increases with particle length. It was found that the relation between α_e and ψ can be given by α_e=A lom ψ+B, where A and B are constants. This relation is recognized in the case of particles of other shape such as lactose granules with different size and shape. The inherent values of A with each sample were observed but the physical meaning of A is still obscure.

• 公益社団法人日本薬学会の論文
• 1974-01-25

著者

• 木村 真太郎

  東邦大学薬学部

• 福沢 寿

  東邦大学薬学部

• 木村 真太郎

  (present Address)pharmacy Of Hospital Attached To The Faculty Of Dentistry Tokyo Medical And Dental

関連論文

• 高分子量マクロゴール中におけるアスピリン結晶の成長と分解
• The Rate of Penetration of Liquid into Tablets. II. Influence of Second Ingredient and Mixing Ratio
• Cohesion of Particulate Solids. VI. Improvement of Apparatus and Application to Measurement of Cohesiveness at Various Levels of Humidity
• The Rate of Penetration of Liquid into Tablets
• Cohesion of Particulate Solids. VIII. Influence of Particle Shape on Compression by Tapping
• Cohesion of Particulate Solids. VII. Influence of Particle Size on Compression by Tapping
• 粉粒体の凝集性(第5報)タッピングによる圧縮応力と粉末薬品の圧縮性
• 粉粒体の凝集性(第4報)流動性と凝集性
• 粉粒体の凝集性(第3報)粒子形態の影響
• 粉粒体の凝集性(第2報)粒径の影響
• 粉粒体の凝集性(第1報) : 凝集力の測定方法(薬剤学)

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