アミノフィリンの溶解および析出過程におよぼすpHの影響

概要

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To study the dissolution behaviour of aminophylline (AP) and the mechanism of the crystallization phenomenon of theophylline (TH) in aqueous solution, the property of interaction of TH with aliphatic amines was investigated. It was observed that the solubility of AP was dependent on its amount fed to water and the maximum solubility appeared at the initial stage of dissolution of AP. The solubility of TH decreases with the crystallization of TH. It was found that the interaction of TH with aliphatic amines was affected by pH of the solution and the stability constants of complexes apparently varied with pH. In the case of ethylenediamine (ED), the molar ratio 2 : 1 (TH : ED) complex was formed at relatively high pH. It was suggested that AP was unstable in water (pH 6-7), dissociated to TH and ED rapidly, and TH crystallized in the solution.
公益社団法人日本薬学会の論文
1982-01-25