イオン性薬物の消化管吸収とその機構

概要

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This paper reviews the researches on the intestinal absorption mechanisms of ionized drugs such as β-lactam antibiotics, quaternary ammonium compounds, and tertiary amines. Although these compounds revealed an ionized form in the gastrointestinal tract, absorption from the intestine was well or rapid, and it has been pointed out that a specialized transport system participated in these absorption processes. As a specialized intestinal absorption mechanism of zwitter ionic β-lactam antibiotics the carrier-mediated transport related to dipeptide absorption and the binding to the intestinal mucosa are discussed. In the case of quaternary ammonium compounds and tertiary amines various absorption systems including the binding to the gastric mucin, active secretion to the intestinal lumen, correlation with choline transport, binding to the brush border membrane, and participation of electrical potential difference across brush border membrane are reviewed.
公益社団法人日本薬学会の論文
1987-04-25