アレーントリカルボニルクロム錯体を用いる高選択的合成法の開発とその医薬合成への応用

概要

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The development of new methodologies for the stereocontrolled synthesis of complex molecules is very important for the efficient synthesis of therapeutic agents. In this review, 1) the stereocontrolled synthesis of exocyclic olefins using arene・Cr (CO)_3-catalyzed 1,4-hydrogenation of conjugated diene and its application to the synthesis of prostacyclin analogs, 2) new catalytic activities of arene・Cr (CO)_3 as a hydrogenation catalyst, 3) the stereocontrolled synthesis of silyl dienol ethers and dienamides using arene・Cr (CO)_3-catalyzed isomerization, and 4) a novel carbon-carbon bond-forming reaction through η^5-pentadienylchromium complexes, are described.
公益社団法人日本薬学会の論文
1994-04-25