ビタミンB_1と金属との関係についての研究 II : ビタミンB_1と銅(II), カドミウム(II)および亜鉛(II)との反応について

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Previous study has shown that red-fluorescent product was formed by reaction of vitamin B_1 with cupric ion, and could be applied to the detection of vitamin B_1. The present report deals with the synthesis and the structure of the product of vitamin B_1 with copper, cadmium and zinc, respectively. In order to find the condition for the synthesis of the product, the effect of metal ion on the stability of vitamin B_1 was examined by determining vitamin B_1. When respective ion of copper (II), cadmium (II) and zinc (II) was reacted with thiolized vitamin B_1 at pH 10〜11,vitamin B_1 was decomposed only by copper vigorously at 37°and slowly at 0°, but the decomposition of vitamin B_1 was hardly observed by any other metal under the experimental conditions. Therefore, their metal salts of vitamin B_1 were synthesized as follows : vitamin B_1-HCl solution (1 mol) was added into NaOH solution (3 mol) at room temperature, after about 45 minutes, the metal ion solution (1 mol) was added to the mixture at pH 10〜11 under cooling and stirring. The precipitate was recrystallized from iso-butanol or iso-propanol. The molar ratio of metal to vitamin B_1 of the crystal was found to be 1 to 2 by chemical analysis. The measurements of U.V. and I.R. spectra of their salts showed the structure of metal chelate.
公益社団法人日本薬学会の論文
1966-08-30