High-Performance Liquid Chromatographic Determination of Estradiol Benzoate in Cosmetics

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概要

• 論文の詳細を見る

• A method for the quantitative determination of estradiol benzoate (EB) in cosmetics by highperformance liquid chromatography (HPLC) was developed. The EB was extracted from samples with methylene chloride, the extract was evaporated, and the residue was subjected to silica gel column chromatography. The column was washed with benzene to remove impurities, and EB was eluted with ethanol-benzene (1 : 9,v/v) and determined by HPLC on an octadecylsilylated silica column using a mobile phase of acetonitrile-water, with UV detection (230 nm). Recoveries of EB obtained from a variety of cosmetic samples spiked at 0.001 and 0.002% levels were 91.8-99.8%, and the coefficients of variation were between 0.41-2.5%. When this method was applied to the analysis of EB in commercial samples, EB could be determined without interference.

• 公益社団法人日本薬学会の論文
• 1984-10-31

著者

• KAMATA Kunihiro

  Tokyo Metropolitan Institute of Public Health

• Kamata Kunihiro

  Tokyo Metropolitan Research Laboratory Of Public Health

• HARADA HIROFUMI

  Tokyo Metropolitan Research Laboratory of Public Health

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• High-Performance Liquid Chromatographic Determination of Estradiol Benzoate in Cosmetics

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