Reduction of Electrically Evoked Neural Activity by Ginseng Saponin in Rat Hippocampal Slices

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概要

• 論文の詳細を見る

• It is well established that ginseng saponin has positive influences on various neural diseases, but little is known about its electrophysiological effects in the central nervous system. In this study, we examined the electrophysiological effects of ginseng saponin in rat hippocampal slices. Total saponin from ginseng root reduced the slope of fEPSPs (field excitatory postsynaptic potentials) in the CA1 area in a dose-dependent manner (9.1±5.4%, 48.4±12.1%, and 60.5±15.3% at 10,50,and 100 μg/ml, respctively), which was reversed within 10 min of washout. Seven different ginsensosides resulted in varied degrees of fEPSPs reduction. The rank order of rduction was Rb1,Rg1>Rg2,Rh1,Rc>Rd, Re within a range of 5-64% reduction. No difference in the suppressive action between protopanaxadiol (Rb1,Rc, Rd) and protopanaxatriol (Rg1,Rg2,Re, Rh1) saponins was shown; the slope of fEPSPs was reduced by 38% and 40% on average, respectively. The possible role of γ-aminobutyric acid (GABA_A) receptor in the suppressive action of ginseng saponins was tested using whole cell patch recording in acutely isolated hippocampal neurons. Ginsenosides did not induce chloride current nor modified GABA-induced current. Also, the suppressive effect of ginsenosides on fEPSPs was still observed in the presence of the GABA_A receptor antagonist, bicuculline methiodide 50 μM. These results suggest that the suppressive effect is not attributable to regulation of GABA_A receptor activation.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• Lee Chang-joong

  Department Of Biology Inha University

• LEE Sang-Hun

  Department of Electrical Engineering, Dankook University

• Park Jin-kyu

  Ginseng And Tabacco Research Institute

• Lee Sang-hun

  Department Of Biology Inha University

• YANG Sung-Chil

  Department of Biology, Inha University

• JUNG Min-Whan

  Neuroscience Laboratory, Institute for Medical Sciences, Ajou University

• Jung Min-whan

  Neuroscience Laboratory Institute For Medical Sciences Ajou University

• Yang Sung-chil

  Department Of Biology Inha University

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