Red Blood Cell Metabolism and Hemoglobin Oxygen Affinity. Effect of Vinburnine on Normobaric Hypoxic Rats

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The influence of Viburnine on red blood cell metabolism and hemoglobin oxygen affinity was investigated in normobaric rats (FiO_2 : 10%). Two periods of hypoxic exposure were performed (10-21d). In each experimental series, rats were divided into two groups : Treated rats received a daily intraperitoneal injection of drug (4 mg/kg). Control rats in the same conditions of hypoxia received an isotoic saline solution.For a 10 d exposure period, Vinburnine does not affect red blood cell metabolism nor hemoglobin oxygen affinity. At 21 d period exposure, 2,3 diphosphoglycerate (2,3 DPG) and ATP amounts increase in treated rats. The rate of increase was 10% (p<0.05) and 28% (p<0.01), respectively. Red blood cell metabolism effect of Vinburnine was not accompanied by a modification in affinity hemoglobin oxygen (Hb-O_2); no statistically significant difference was observed between treated rats and control rats concerning p50 (partial pressure oxygen at half hemoglobin saturation).Results suggest that Vinburnine has a metabolic effect corresponding to a glycolysis anaerobic stimulation, which can improve oxygen delivery to tissues and could explain the favorable hemoreological action of Vinburnine observed in a previous investigation.
公益社団法人日本薬学会の論文
1999-08-15