Effects of Flecainide on Ventricular Arrhythmias, Abnormal Automaticity and Activation in a Canine Model of Myocardial Infarction

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概要

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• Effects of flecainide, a class I antiarrhythmic drug, on ventricular arrhythmias, ventricular abnormal automaticity and ventricular activation were examined in a canine model of myocardial infarction, and compared with those of lidocaine. The effects of the drugs were examined on (1) the arrhythmias developed 24 h after the left anterior descending coronary artery (LAD) ligation, (2) ventricular premature stimulation-induced arrhythmias 5 to 7 d after LAD ligation, (3) ventricular abnormal automaticity about 24 h after LAD ligation and (4) ventricular activation induced by a ventricular stimulation at various coupling intervals in animals 5 to 7 d after LAD ligation. Flecainide (1 and 3 mg/kg) showed a marked reduction in the frequency of ventricular ectopic beats 24 h after LAD ligation, and was more potent than lidocaine. The ventricular abnormal automaticity was inhibited by flecainide (1 and 3 mg/kg) and lidocaine (10 mg/kg). Flecainide (1 and 3 mg/kg) prolonged the activation time in the infarcted zones over a wide range of the coupling intervals, and produced block of seriously delayed activation. In contrast, lidocaine produced similar effects only at short coupling intervals. Ventricular premature stimulation produced ventricular arrhythmias, which were prevented by pretreatment with flecainide (3 mg/kg). In conclusion, flecainide showed antiarrhythmic effects in a canine model of myocardial infarction. A marked inhibition of ventricular abnormal automaticity and selective depression of delayed activation in the infarcted zone probably contribute to its antiarrhythmic effect.

• 公益社団法人日本薬学会の論文

著者

• HASHIMOTO Hisakuni

  Fujinomiya City General Hospital

• NAKASHIMA Mitsuyoshi

  Fujinomiya City General Hospital

• Hashimoto Hisakuni

  Fujinomiya City General Hospital:department Of Pharmacology Hamamatsu University School Of Medicine

• Nakashima Mitsuyoshi

  Fujinomiya City General Hospital:department Of Pharmacology Hamamatsu University School Of Medicine

• KATOH Hiroshi

  Fujinomiya City General Hospital

• Katoh H

  Fujinomiya City General Hospital:department Of Pharmacology Hamamatsu University School Of Medicine

関連論文

• Comparison of the Effects of Halothane and Propranolol on the Effective Refractory Period and the Ventricular Activation in a Canine Myocardial Infarction Model
• A Differential Alteration in the Responsiveness of Isolated Cardiac Muscles to Alpha-and Beta-adrenergic Agonists in DOCA-Salt Hypertensive Rats
• Effects of Flecainide on Ventricular Arrhythmias, Abnormal Automaticity and Activation in a Canine Model of Myocardial Infarction
• Electrophysiologic Interaction between Class I Antiarrhythmic Drugs and Volatile Anesthetics in Depressant Effects on Ventricular Activation in a Canine Myocardial Infarction Model.
• Increases in alpha-but not beta-adrenoceptors in hypertrophied non-infarcted cardiac muscles from rats with chronic myocardial infarction.

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