Effect of Pre-administered Fats and Fatty Acids on the Intestinal Absorption of Tryptophan in the Rat

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The effects of pre-administered fats and fatty acids on the absorption of tryptophan from the rat small intestine were investigated using in situ recirculation and in vitro everted sac techniques. Pre-administration of octanoic acid significantly inhibited the absorption of L-tryptophan, and this effect was not rapidly reversible. Trioctanoin, oleic acid, methyl octanoate, and octyl alcohol modestly inhibited the absorption of L-tryptophan, while triolein and olive oil did not significantly affect. The maximal transport capacity (V_<max>) seemed to be affected rather than Michaelis constant (K_m) by the administration of octanoic acid. Pre-administration of octanoic acid also inhibited the transport of L-tryptophan in vitro. In contrast, the absorption of D-tryptophan was partially inhibited by octanoic acid. With the pre-administration of octanoic acid there was an increase in the amount of protein released into the perfusate when compared to the control or the administration of other lipids. It is possible that the effect of pre-administered octanoic acid on the intestinal absorption of tryptophan may be due to the loss of structural and/or functional integrity of the intestinal membrane.
公益社団法人日本薬学会の論文
1976-12-25