Analysis of the Correlation between Collagen and Desoxyribonucleic Acid Syntheses under the Influence of Hydroxyurea in the Inflammatory Connective Tissue

スポンサーリンク

概要

• 論文の詳細を見る

• A significant inhibition of desoxyribonucleic acid (DNA) synthesis in rat granuloma cells was brought about by 6 repeated administrations (250 mg/kg) of hydroxyurea at 12 hr intervals from day 5 to day 7 after carrageenan injection. The suppressive effect of hydroxyurea on the amount of DNA in granulomatous tissue began to appear on day 8 (12 hr after the last injection of hydroxyurea), and then a maximum inhibition was attained on day 9. The inhibitory effect on the amount of collagen, on the other hand, was disclosed on day 9 with the retardation of around one day to the appearance of suppressive effect on DNA. The cellular activity for collagen synthesis in the hydroxyurea-treated group was gradually elevated accompanying coincidental suppression of DNA synthesis, suggesting that mature cells synthesized collagen more actively than newly formed cells. Suppression of cell proliferation by hydroxyurea seems to result in decrease in the number of mature cells with the retardation of time required for maturation of newly formed cells.

• 社団法人日本薬学会の論文
• 1976-11-25

著者

• 申 國鉉

  Pharmaceutical Institute, Tohoku University

• 鶴藤 丞

  Pharmaceutical Institute, Tohoku University

• 鶴藤 丞

  Pharmaceutical Institute Tohoku University

• 鶴藤 丞

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 申 國鉉

  Pharmaceutical Institute Tohoku University

関連論文

• Analysis of the Correlation between Collagen and Desoxyribonucleic Acid Syntheses under the Influence of Hydroxyurea in the Inflammatory Connective Tissue
• Analysis of Time Sequence of Glucocorticoid Action on Granulomatous Inflammation
• Rebound of Vascular Permeability Response and Its Inhibition by Hydroxyurea in Granulomatous Inflammation Following Withdrawal of Glucocorticoid Therapy
• 細胞間マトリックスの加齢変化 (第16回日本老年医学会総会記録) -- (老化と結合組織)
• Detoxication and Excretion of Radioactive Strontium. IV. Effect of Sodium Calcium Citrate and the Mode of Action of Citrate.
• Effect of Phosphorus-deficient Diet with Excess of Calcium or Strontium on the Excretion of Radiostrontium and Its Possible Mechanism
• Detoxication and Excretion of Radioactive Strontium. II. Effect of Several Organic Acids having Chelating Ability.
• Detoxication and Excretion of Radioactive Strontium. III. Effect of Tricarballylic and Lactic Acids.
• 唾液腺ホルモンの研究-23-

スポンサーリンク