Measurement of the Distribution Parameter in Solubilized Systems. III. Measurement of the Distribution Parameter of Drugs Which Show Blue or Red Shifts in the Surfactant Solution and Its Utilization for Discrimination
スポンサーリンク
概要
- 論文の詳細を見る
There are two types of shift of absorption spectrum at surfactant concentrations above the citical micelle concentration, one is the system shifting to a longer wavelenth side (red shift; alkylparaben-sodium dodecyl sulfate (SDS) solution system, alkyl gallate-cetyl trimethylammonium bromide (CTAB) solution system, etc.) and the other is the system shifting to a shorter wavelength side (blue shift; sorbic acid-SDS solution system, benzoic acid-CTAB solution system, etc.). The distribution parameter values can be obtained through measuring the shift-length of the maximum absorption wavelength by the first derivative absorption spectrum (FDAS-SL method), regardless of their shift direction.It was confirmed that in a case where discrimination by the absorption spectrum of drugs is difficults (for example, alkylparabens), measurement of the distribution parameter values is a good alternative. In the case of alkylparabens, discrimination was easily attained in the order of SDS (anionic)>CTAB (cationic)>octaethylene glycol monododecyl ether>polyoxyethylene (20) sorbitan monolaurate (nonionic) solution. Room temperature was the best condition for the measurement.
- 公益社団法人日本薬学会の論文
- 1991-10-25
著者
-
清水 澄
Faculty Of Pharmaceutical Sciences Teikyo University
-
岩鶴 素治
帝京大・薬・薬剤学教室
-
岩鶴 素治
Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
今田 智栄美
Faculty of Pharmaceutical Sciences, Teikyo University
-
今田 智栄美
Faculty Of Pharmaceutical Sciences Teikyo University
関連論文
- モノクローナル抗体を用いた癌 Targeting 療法の免疫学的問題点とその改善
- 合成膜融合タンパクJTS-1を用いた遺伝子導入効率の検討
- ボロン化合物封入トランスフェリン-PEG-リポソームによる中性子捕捉療法
- トランスフェリン-ポリリジン- plasmid DNA コンプレックスによるK562細胞への遺伝子導入とその高効率化
- Naked plasmid DNA のマウス尾静注後の遺伝子発現
- ペンダント型ポリエチレングリコール修飾イムノリポソームのターゲティング特性
- 膜融合能を有するポリエチレングリコール誘導体を組み込んだイムノリポソームの調整及びその特性に関する基礎的検討
- PEG-イムノリポソームのターゲティング特性とそのアドリアマイシン封入体の調製
- ステルスイムノリポソーム : 抗体-ポリエチレングリコール修飾リポソームの調製とその標的指向性の評価
- トランスフェリン修飾PEG-リポソームをキャリアーとした癌細胞内ターゲティング
- Colorimetric Determination in the Frozen State with Dual-Wavelength Spectrophotometer. Application to the Kinetics of Hydrolysis of p-Nitrophenyl Acetate
- ドキソルビシン封入ポリエチレングリコール修飾リポソームの骨髄毒性
- ポリエチレングリコール修飾リポソームへのドキソルビシン封入方法と安定性の評価
- サルファ剤とジメチルアミン間の分子付加物の形成とその微粉化への応用性
- バルビツール酸誘導体, その関連化合物とジメチルアミン間の分子付加物の形成ならびにその微粉化への応用
- バルビツール酸誘導体とジメチルアミン間の分子付加物の形成
- Ammonia Adducts of Barbiturates and Their Application to Particle Size Reduction
- ポリエチレングリコール付与血中滞留型リポソームの徐放担体への応用
- EFFECT OF MOLECULAR WEIGHT IN AMPHIPATHIC POLYETHYLENEGLYCOL ON PROLONGING THE CIRCULATION TIME OF LARGE UNILAMELLAR LIPOSOMES
- Antitumor Activity of Doxorubicin Encapsulated in Poly (ethylene glycol)-Coated Liposomes
- Application of the First Derivative Absorption Spectrum-Shift-Length Method to the Simultaneous Determination of Binary Mixture
- Measurement of the Distribution Parameter in Solubilized Systems. III. Measurement of the Distribution Parameter of Drugs Which Show Blue or Red Shifts in the Surfactant Solution and Its Utilization for Discrimination
- Measurement of the Critical Micelle Concentration of Nonionic-Nonionic Mixed Surfactant Systems by the First Derivative Absorption Spectrum Method and the Region of Cooperative Micelles
- Measurement of the Critical Micelle Concentration of Ionic-Nonionic Mixed Micelles by the First Derivative Absorption Spectrum Method
- Measurement of the Critical Micelle Concentration of Nonionic Surfactants by the First Derivative Absorption Spectrum Method
- Measurement of the Distribution Parameter in Solubilized Systems. II. : Measurement of the Distribution Parameter of Alkylparabens and Alkyl Gallates in Ionic and Nonionic Surfactant Solutions
- Application of Double-Reciprocal Plot between the Shift-Length of Absorption Maxima of Solubilized Alkylparabens and Sodium Dodecyl Sulfate Concentration to the Determination of the Distribution Parameter
- Measurement of the Distribution Parameter in Solubilized Systems. Application of the Derivative Spectrum Method to Alkylparabens Solubilized with Sodium Dodecyl Sulfate
- ステロイド白内障と肝機能変化との関連 : 鶏胚ステロイド誘発白内障モデルからの考察
- ステロイド白内障と肝機能変化との関連 : 鶏胚ステロイド誘発白内障モデルからの考察
- PEGリポソームの凍結乾燥による物性の変化
- Characterization of the Benzodiazepine Binding Site (Diazepam Site) on Human Serum Albumin
- Effects of Fatty Acid on the Specific Drug-Binding Sites of Human Serum Albumin
- Location of Drug Binding Sites on Human Serum Albumin
- Classification of Drugs on the Basis of Bilirubin-Displacing Effect on Human Serum Albumin
- The Classification of Drugs on the Basis of the Drug-binding Site on Human Serum Albumin
- The Stabilization Mechanism of Acylcholinesters in Aqueous Solution by Sodium Lauryl Sulfate
- Studies on Methods of Particle Size Reduction of Medicinal Compounds. VI. Solvate Formation of Griseofulvin with Benzene and Dioxane
- Determination of Particle Size and Its Distribution of Drug Powder by Dissolution Rate Measurements
- 二波長測光法による牛血清アルブミン・アシッドバイオレット6B結合量の測定
- 牛血清アルブミンと結合したナフトール・イ***ーSの第二の結合形スペクトルの推定
- 吸光光度法の実際-失敗例から解く分析実践シリーズ-, 高田芳矩著, A5判, 144頁, 1800円, (講談社サイエンテイフイク)