Synthesis of α-Deuterium-Labelled Cyclohexylamine and Its Deamination by Rabbit Liver Microsomes
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概要
- 論文の詳細を見る
In order to investigate the isotope effect on the microsomal oxidative deamination of cyclohexylamine, α-deuterium(D)-labelled cyclohexylamine was synthesized. The deuterium labelling was found exclusively at the α-position with a purity of greater than 99 atom percent. Metabolic studies in vitro indicate that a significant deuterium isotope effect operates in the oxidative deamination of α-D-labelled cyclohexylamine. On incubation with rabbit liver microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and oxygen, the ratio of apparent deamination rate constants (k_H/k_D) was 2.0±0.2 (mean±S.D.).
- 公益社団法人日本薬学会の論文
- 1989-04-25
著者
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田中 彰
National Institute of Hygienic Sciences
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田中 彰
昭和薬科大学
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紅林 秀雄
National Institute of Hygienic Sciences
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福岡 正道
National Institute of Hygienic Sciences
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