Changes in Electroencephalograms of Rats during the Development of Stress Ulcer

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Electrocorticograms in restrained rats and in restrained and water (35°)-immersed rats showed a series of cycles fluctuating between low voltage rhythmical waves and high voltage irregular waves including spindles and spikes during a 6-hr stress period, whereas those in restrained and water (25°)-immersed rats showed a succession of low voltage rhythmical waves whose initial increased frequency gradually decreased below the original levels as the stress period was prolonged. Hippocampal electrical activities fluctuated in parallel with the cortical activities. A specific gastric motility, a severe gastric ulceration, and a marked hypothermia were observed only in the restrained and water (25°)-immersed rats. Acute adrenalectomy in the restrained and water (25°)-immersed group more decreased frequencies of the rhythmical low voltage waves and induced abnormal waves such as discharges and wave flattening with high mortality. These changes could be retarded by epinephrine or corticosterone administration but not by ACTH administration.
社団法人日本薬学会の論文
1978-03-25