Synthesis of Pyridazine Derivatives. VIII. Nucleophilic Substitution of 3,6-Dichloro-4-methylpyridazine.

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概要

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• In the reaction of 3,6-dichloro-4-methylpyridazine (I) with hydrazine hydrate, ammonia, sodium hydroxide, sodium methoxide, or potassium hydrogen sulfide, monosubstituted compounds were obtained. The position of methyl group in those compounds and the relationship among them were cleared up. Examination was also made on whether substitution in (I) occurred in 3- or in 6-position according to the change of conditions. 6-Chloro-8-methyl-s-triazolo [4,3-b] pyridazine and 6-chloro-7-methyl-s-triazolo [4,3-b]-pyridazine were prepared from 3-hydrazino-4-methyl-6-chloropyridazine and 3-hydrazino-5-methyl-6-chloropyridazine, and were derived to their 6-hydrazino derivatives.

• 公益社団法人日本薬学会の論文

著者

• 高林 昇

  Pharmaceutical Faculty, University of Toyama

• 高林 昇

  Pharmaceutical Faculty University Of Toyama

関連論文

• Synthesis of 6-Substituted 3-Sulfanylamido-5-methylpyridazines
• Synthesis of Pyridazine Derivatives. IX. On the Oxidation Products of Sulfur-containing Compounds of Pyridazine. (3).
• Synthesis of Pyridazine Derivatives. VIII. Nucleophilic Substitution of 3,6-Dichloro-4-methylpyridazine.

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