Chameleonic Effect and Some Models for Predicting Drug Solubility in Solvent Mixtures

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概要

• 論文の詳細を見る

• A new model derived from an excess free energy approach which expresses drug solubility in solvent mixtures showing multiple solubility peaks, the chameleonic effect, with respect to the concentrations of solvents in a mixture is proposed. Accuracy and predictability of the model are compared with those of a previous model which expresses drug solubility based on Hildebrand, acidic and basic solubility parameters. The results indicate that the new model is more accurate than the previous model and average percent mean errors are 5.32 and 13.66,respectively.

• 公益社団法人日本薬学会の論文
• 1997-08-15

著者

• Jouyban-gharamaleki Abolghasem

  Department Of Pharmaceutical Chemistry School Of Pharmacy Tabriz University Of Medical Sciences

関連論文

• The Modified Wilson Model and Predicting Drug Solubility in Water-Cosolvent Mixtures
• Chameleonic Effect and Some Models for Predicting Drug Solubility in Solvent Mixtures

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