放射線治療における不確定度 5% への挑戦

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The effect of radiation treatment depends upon doses delivered to the region of both the tumor and healthy tissue. Therefore, the most important factors for successful of the radiation treatment is not only the accuracy of the dose in the target volume but also the dose in the tissues surrounding the tumor. ICRU Report 24 recommends that the dose accuracy at the target volume should be within 5% of uncertainty. However, the radiation treatment process contains several steps such as clinical examinations, patient data acquisition, treatment planning, etc. Each of these steps may introduce a significant uncertainty in the delivered dose. This paper discusses those factors that can cause dose uncertainty and suggests how to reduce the uncertainty to within 5%. The uncertainty in the radiation theapy process are : 1) Dose measurement at the reference point of waterphantom. This is about 5%. 2) Dose calculation due to an algorithm error. This error, without consideration of patient heterogeneity, is 6% for inhomogeneity correction. 3) Patient setup variations in daily treatment. These errors are estimated to be about 4.2%. According to our research at Aichi Cancer Center Hospital, based on the analysis of all these factors, the overall uncertainty has been estimated over 9%. To improve the above uncertainties, it would be important (or essential) : 1) to calibrate the dose monitor of the linear acceralator frequently, 2) to reduce the errors during the process of acquiring patient information, 3) to develop a treatment planning system which performs more accurate and faster dose computation with any sophisticated inhomogeneity correction, 4) to introduce special treatment techniques such as dose radiation with synchronized patient aspiration so as to insure reproducability of patient orientation, and 5) to stabilize the radiation energy of the source. By implementing the above, the overall uncertainty is estimated to be 6%.
公益社団法人日本放射線技術学会の論文
1992-01-01

放射線治療における不確定度 5% への挑戦

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