放射線治療によって生じた口腔内乾燥症と唾液分泌障害の回復時期について

概要

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Between June 1995 and August 1997, we treated 23 patients with head and neck malignancies using an xray beam and then interviewed the patients to determine the degree of subjective salivary secretion and xerostomia after long-term radiation therapy. Interviews were continued for a maximum 179 weeks(mean, 76.3 weeks)after irradiation. We scored the results as the degree of subjective salivary secretion, then noted the recovery time for salivary secretion and xerostomia. When salivary glands had been irradiated to a total dose of 30 to 60 Gy, salivary secretion and oral dryness recovered within three years in 72%(13/18)and 67%(13/18)of the patients, respectively. However, these symptoms never recovered to their original levels when the total dose was more than 60 Gy. The acute and late effects of radiation therapy may induce a risk of dental caries, oral dryness, and osteoradionecrosis as well as taste impairment. Therefore, education as to dental and oral care is mandatory for patients who will be or who have been treated with radiotherapy.
公益社団法人日本放射線技術学会の論文
2000-10-20