非侵襲的局所脳血流量測定BUR法における大動脈弓部ROI設定位置の再現性向上の工夫とガンマフィッティングの自動化

概要

論文の詳細を見る
The brain uptake ratio (BUR) is useful for non-invasive cerebral blood flow measurements. To obtain this ratio requires setting an ROI on the aorta to draw the time-activity curve (TAG). Previously, the ROI has been manually set, in order to avoid two undesirable positionings: l) protrusion from the aorta and 2) overlap in a vein or lung. However, these manual methods are affected by operator subjectivity, which results in individual variations in TAG. In calculating the area under the curve (AUC), gamma fitting of TAG is also affected by operator subjectivity. These subjective operations are considered to be an important impediment to the reproducibility of AUC. Better reproducibility of AUC would lead to improved measurement of brain perfusion. In this study, two newly devised trials were undertaken: l) defining a system for setting ROI on the aorta; 2) and automatic gamma fitting for TAG. As a result of these trials, the individual variation in AUC among operators decreased, and the reproducibility of AUC was enhanced.
公益社団法人日本放射線技術学会の論文
2003-12-20