Species Differences in the Distribution of the Nonmuscle Myosin Heavy Chain IIB Inserted Isoform in the Brain(Biochemistry)
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概要
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The alternatively spliced isoform of the nonmuscle myosin heavy chain IIB (MHC-IIB) with an insert of 21 amino acids near the actin-binding region, MHC-IIB (B2), is expressed specifically in the brain and spinal cord in Mammalia and Aves. We performed immunoblot analyses to elucidate the distribution of MHC-IIB (B2) in the brains of various animals. Nearly half of MHC-IIB existed as the B2 inserted isoform (MHC-IIB (B2)) in the cerebrum of the guinea-pig, rabbit and pig, while the non-B2 inserted isoform (MHC-IIB (ΔB2)) was the dominant form in the cerebrum of the rat, mouse and hamster. In the guinea-pig, the amount of MHC-IIB (B2) expressed in the cerebrum was low compared to MHC-IIB (ΔB2) during the first postnatal week, but it increased to comparable levels during postnatal development. In the rat, the amount of MHC-IIB (B2) protein in the cerebrum remains low compared to its expression elsewhere in the brain throughout life. Our results regarding the distribution of MHC-IIB (B2) in the adult brain lead us to classify species into two types ; one type expresses significantly less MHC-IIB (B2) in the cerebrum than in other portions of the brain, and the second type expresses it at comparable levels throughout the brain. Based on these results, we hypothesize that MHC-IIB (B2) modulates the role of MHC-IIB (ΔB2) in the regulation of synaptic structure and function in the mature brain, and that the requirements for such function by MHC-IIB (B2) have shifted gradually from the cerebellum to the cerebrum with evolutionary increases in brain size.
- 社団法人日本動物学会の論文
- 2001-01-20
著者
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TAKAHASHI Masayuki
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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YAMAGISHI Akihiko
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Yamagishi A
Ochanomizu University
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Hagiwara Shin-ya
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Yamagishi A
Univ. Tokyo
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Hagiwara Shin-ya
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Yamagishi Akihiko
Division Of Biological Science Graduate School Of Science Hokkaido University
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Takahashi Masayuki
Division Of Biological Science Graduate School Of Science Hokkaido University
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Takahashi Masayuki
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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